⚠️ 2024: Multiple health incidents linked to red yeast rice (Monascus purpureus) supplements (Kobayashi Pharmaceutical). Consult your doctor before using red yeast rice products.
🔬 Regularly Updated

Fermentation Bacteria Database

Latest science on the microbes behind Japanese fermented foods

18
Registered Species
16
Safe / Relatively Safe
2
Dangerous / Caution
🆕 4
New Discoveries
※ Included in total count

🧭 About the 5-Level Safety Rating

💚 Lv.5: Very Safe
🟢 Lv.4: Relatively Safe
🟡 Lv.3: Caution
🟠 Lv.2: Dangerous
🔴 Lv.1: Very Dangerous
traditional

Koji Mold

Aspergillus oryzae

💚 Lv.5
Very Safe

Japan's designated "National Fungus." This filamentous mold is used in koji production and generates abundant enzymes (amylase, protease) that break down starch and proteins. It forms the foundation of Japan's fermented food culture.

✅ Benefits
  • Improves gut microbiome & digestion
  • Boosts immunity (β-glucan production)
  • Promotes vitamin B complex synthesis
  • +2 more…
⚠️ Risks
  • Hypersensitivity pneumonitis from spore inhalation (allergy-prone individuals)
  • Risk of excess sodium/sugar with overconsumption

⚗️ Reactions with Substances

Oxygen (O₂) (Safe) High-concentration ethanol (Neutral) Spore inhalation (large amounts) (Caution)
#Brewing#Koji#National Fungus#Probiotics
traditional

Natto Bacillus

Bacillus subtilis var. natto

💚 Lv.5
Very Safe

A variant of Bacillus subtilis that ferments soybeans into natto. Forms heat-resistant spores that survive 100°C. Produces nattokinase, a thrombolytic enzyme drawing attention for cardiovascular disease prevention.

✅ Benefits
  • Prevents blood clots (nattokinase)
  • Prevents osteoporosis (vitamin K₂ production)
  • Improves gut microbiome
  • +2 more…
⚠️ Risks
  • Avoid if taking warfarin (vitamin K₂ antagonism)
  • Excess uric acid from purines with overconsumption

⚗️ Reactions with Substances

Ammonia (NH₃) production (Safe) Vitamin K₂ (Caution) High temperature (100°C) (Neutral)
#Natto#Nattokinase#Thrombosis prevention#Vitamin K2
caution ⚠️ Dangerous

Red Yeast Rice Mold

Monascus purpureus

🟠 Lv.2
Dangerous

【2024 MAJOR WARNING】Multiple kidney disease cases and deaths reported due to Kobayashi Pharmaceutical's red yeast rice supplement. May produce harmful substances including citrinin (nephrotoxin) and puberulic acid. The Ministry of Health is conducting ongoing investigations.

⚠️ March–April 2024: Kobayashi Pharmaceutical's 'Beni Koji Choleste Help' caused multiple deaths and hospitalizations. Consumer Affairs Agency and MHLW ordered recall.
✅ Benefits
  • LDL cholesterol reduction (monacolin K)
  • Blood pressure lowering (some studies)
⚠️ Risks
  • Kidney damage/failure (deaths reported in Japan 2024)
  • Liver/kidney toxicity from citrinin
  • Organ damage from puberulic acid
  • +2 more…

⚗️ Reactions with Substances

Citrinin (produced toxin) (Danger) Puberulic acid (produced toxin) (Danger) Statin drugs (Danger) Monacolin K (Caution)
#Warning#MHLW investigation#Supplement#Kidney damage#2024 issue
lactic

Plant-based Lactic Acid Bacteria (LP)

Lactiplantibacillus plantarum

💚 Lv.5
Very Safe

A plant-based lactic acid bacterium highly resistant to stomach acid and bile, reaching the intestines alive. Numerous superior strains have been discovered in traditional Japanese pickles (nukadoko, nozawana), making it one of the most actively researched lactic acid bacteria.

✅ Benefits
  • Improves gut microbiome
  • Immune modulation (promotes IgA production)
  • Anti-allergic effects
  • +2 more…
⚠️ Risks
  • Rare: bloating from excess gas production
  • Caution for those on immunosuppressants

⚗️ Reactions with Substances

Lactic acid (produced) (Safe) Bacteriocin (Safe) Stomach acid & bile (Safe)
#Lactic acid bacteria#Pickles#Gut microbiome#Immunity#Probiotics
lactic

Salt-tolerant Lactic Acid Bacteria

Tetragenococcus halophilus

💚 Lv.5
Very Safe

A unique lactic acid bacterium that thrives in up to 18% salt concentration. Essential for maturing soy sauce and miso, contributing to umami (glutamic acid) production. Recently attracting attention for hypertension prevention.

✅ Benefits
  • Improves gut microbiome
  • Blood pressure reduction (GABA production)
  • Enhances umami flavor
  • +1 more…
⚠️ Risks
  • None (confirmed high safety profile)

⚗️ Reactions with Substances

High salt (up to 18%) (Safe) GABA (produced) (Safe)
#Soy sauce#Miso#Salt-tolerant#GABA#Umami
traditional

Acetic Acid Bacteria

Acetobacter pasteurianus

🟢 Lv.4
Relatively Safe

Acetic acid bacteria that oxidize ethanol into acetic acid. Unique strains exist in Japanese black vinegar (tsubozu), which is rich in amino acids. Recent studies are revealing mechanisms behind its fatigue recovery and weight management effects.

✅ Benefits
  • Promotes breakdown of fatigue-causing lactic acid
  • Suppresses blood sugar spikes
  • Reduces visceral fat
  • +2 more…
⚠️ Risks
  • Tooth enamel erosion (undiluted intake)
  • Risk of worsening gastritis/ulcers (overconsumption)
  • Interaction with diuretic medications

⚗️ Reactions with Substances

Ethanol (CH₃CH₂OH) (Safe) Acetic acid (high concentration) (Caution) Oxygen (O₂) (Safe)
#Vinegar#Black vinegar#Fatigue recovery#Blood sugar#Diet
traditional

Awamori Koji Mold (Black Koji)

Aspergillus luchuensis

💚 Lv.5
Very Safe

Black koji mold used in Okinawa's awamori. Officially classified as an independent species in 2012. Produces large amounts of citric acid, preventing contamination. Essential for shochu production suited to Japan's climate.

✅ Benefits
  • Fatigue recovery via citric acid
  • Antimicrobial effect (contamination prevention)
  • Stress relief with moderate consumption
⚠️ Risks
  • Occupational respiratory disease from spore inhalation (industry workers)
  • Health risks from excessive alcohol consumption

⚗️ Reactions with Substances

Citric acid (produced) (Safe) Black spore inhalation (Caution)
#Awamori#Shochu#Black koji#Citric acid#Okinawa
danger ⚠️ Dangerous

Botulinum Bacteria

Clostridium botulinum

🔴 Lv.1
Very Dangerous

【MAXIMUM DANGER】An anaerobic bacterium producing the most potent neurotoxin in nature (botulinum toxin). Contamination in sealed low-acid foods (honey, izushi, homemade preserves) is a concern. Honey is strictly forbidden for infants under 1 year old.

🚨 Honey, homemade vegetable juice, and corn syrup are strictly forbidden for infants under 1. Adults should also take care with homemade preserved foods (izushi, home-canned goods).
✅ Benefits
  • Medical use: Botox (neuromuscular disorders, cosmetic medicine)
⚠️ Risks
  • Death from respiratory paralysis (botulism)
  • Difficulty swallowing, speech impairment
  • Double vision, pupil dilation
  • +2 more…

⚗️ Reactions with Substances

Spores (heat-resistant) (Danger) Botulinum toxin (produced) (Danger) Oxygen (O₂) (Safe) Low pH (acidic conditions) (Safe) Salt (high concentration) (Safe)
#Danger#Food poisoning#Neurotoxin#Infant#Strictly forbidden
lactic

Sake Lactic Acid Bacteria

Lactobacillus sakei

💚 Lv.5
Very Safe

Lactic acid bacteria found in sake's 'shubo' (yeast starter). Highly resistant to low temperatures and high alcohol. Recently confirmed in clinical studies to improve atopic dermatitis, gaining attention as a functional ingredient.

✅ Benefits
  • Improves atopic dermatitis (clinical trials confirmed)
  • Improves gut microbiome
  • Food preservation via antimicrobial peptides
  • +1 more…
⚠️ Risks
  • None (confirmed high safety)

⚗️ Reactions with Substances

Alcohol (low concentration) (Safe) Lactic acid (produced) (Safe)
#Sake#Yeast starter#Atopy#Skin#Immunity
traditional

Soy Sauce Yeast

Zygosaccharomyces rouxii

💚 Lv.5
Very Safe

An osmotolerant yeast adapted to high-salt and high-sugar environments. Produces HEMF, soy sauce's signature aroma compound, making it the key player in soy sauce flavor. Also involved in umeboshi fermentation.

✅ Benefits
  • Antioxidant production (HEMF etc.)
  • Improves food preservation
  • Generates umami and flavor compounds
⚠️ Risks
  • Can become a contamination source in food manufacturing (industrial issue)

⚗️ Reactions with Substances

High salt (20%+) (Safe) Aroma compound (HEMF) (Safe)
#Soy sauce#Miso#Aroma#Salt-tolerant#Umami
lactic

Pediococcus (Umami LAB)

Pediococcus pentosaceus

🟢 Lv.4
Relatively Safe

One of the main lactic acid bacteria in nukadoko (rice bran bed). Produces pediocin, a bacteriocin that suppresses food poisoning bacteria like Listeria. Research into food preservation applications is advancing.

✅ Benefits
  • Improves gut microbiome
  • Suppresses food poisoning bacteria (Listeria)
  • Improves food shelf life
  • +1 more…
⚠️ Risks
  • Rare: gas and bloating from excess lactic acid production

⚗️ Reactions with Substances

Pediocin (produced) (Safe) Lactic acid (produced) (Safe)
#Nukaduke#Lactic acid bacteria#Food preservation#Bacteriocin
lactic

Bifidobacterium

Bifidobacterium longum

💚 Lv.5
Very Safe

The most abundant beneficial bacterium in the human gut. Dominant in breastfed infants and decreases with age. Recent research on the 'gut-brain axis' connection to depression and anxiety disorders is progressing rapidly.

✅ Benefits
  • Improves gut health & bowel regularity
  • Boosts immunity
  • Colon cancer prevention (short-chain fatty acid production)
  • +2 more…
⚠️ Risks
  • Rare: initial digestive discomfort
  • Bacteremia risk in severe immunocompromised patients (extremely rare)

⚗️ Reactions with Substances

Acetic & lactic acid (produced) (Safe) Short-chain fatty acids (produced) (Safe)
#Yogurt#Gut#Probiotics#Gut-brain axis#Immunity
traditional

Sake Yeast (Kyokai Yeast)

Saccharomyces cerevisiae(清酒系)

💚 Lv.5
Very Safe

The 'Kyokai yeast' managed by the Brewing Society of Japan supports sake quality. Numbered 1 through 28, each has different aroma and flavor profiles. Latest research highlights the functional compound glutathione produced by these yeasts.

✅ Benefits
  • Glutathione (antioxidant) production
  • Vitamin B complex supply
  • Blood flow improvement with moderate consumption
  • +1 more…
⚠️ Risks
  • Liver damage from excessive alcohol consumption
  • Elevated uric acid (purines)
  • Risk of alcohol dependence

⚗️ Reactions with Substances

Ethanol (produced) (Caution) Carbon dioxide (CO₂) production (Caution) Glutathione (produced) (Safe)
#Sake#Japanese rice wine#Yeast#Glutathione#Kyokai
traditional

Soy Sauce Koji Mold

Aspergillus sojae

💚 Lv.5
Very Safe

A koji mold specialized for soy sauce production. Features exceptionally high protease activity, efficiently breaking down soy protein into umami amino acids. Recently studied for its role in breaking down isoflavone glycosides with potential cancer-prevention effects.

✅ Benefits
  • Rich production of umami (glutamic acid)
  • Involvement in isoflavone bioactivation
  • Promotes digestion and absorption (protease)
⚠️ Risks
  • None (equivalent safety to koji mold)
  • Allergic reaction from large spore inhalation (occupational)

⚗️ Reactions with Substances

Isoflavone glycosides (Safe) Soy protein (Safe)
#Soy sauce#Koji#Soybean#Umami#Isoflavone
new 🆕 New

Amazake Yeast (New Finding)

Kazachstania humilis

🟢 Lv.4
Relatively Safe

A 2022 study confirmed this species' involvement in some traditional amazake. The previously overlooked role of yeast in amazake fermentation is becoming clearer. Has unique sugar metabolism suited to low-alcohol fermentation.

✅ Benefits
  • Supports digestive enzyme (amylase) production
  • Natural yeast-specific flavor formation
  • Safety in low-alcohol fermentation
⚠️ Risks
  • Risk of confusion with Candida (research misconception)
  • Rare: excess acidity from over-fermentation

⚗️ Reactions with Substances

Starch & sugars (Safe)
#New finding#Amazake#Natural yeast#Low alcohol#2022
new 🆕 New

Oral-Intestinal LAB (New Research)

Ligilactobacillus salivarius

🟢 Lv.4
Relatively Safe

Reclassified into the new genus 'Ligilactobacillus' in a 2020 phylogenetic revision. Uniquely inhabits both the oral cavity and intestines. Research is ongoing into applications for both periodontal disease prevention and intestinal immunity.

✅ Benefits
  • Suppresses periodontal bacteria (P. gingivalis)
  • Reduces bad breath
  • Activates intestinal immunity
  • +1 more…
⚠️ Risks
  • None identified

⚗️ Reactions with Substances

Bacteriocin (produced) (Safe)
#New finding#Oral#Periodontal disease#LAB#Reclassified
new 🆕 New

Natto Bacillus DG101 (Next-gen Probiotic)

Bacillus subtilis DG101

💚 Lv.5
Very Safe

A novel Bacillus subtilis strain isolated from traditional Japanese natto. Highly resistant to stomach acid, bile, and lysozyme, reaching the intestines alive. A next-generation probiotic confirmed in randomized double-blind trials to improve body weight, blood sugar, and cholesterol.

✅ Benefits
  • Significant reduction in body weight, BMI, and body fat (confirmed in clinical trials)
  • Improved blood glucose, HbA1c, and insulin (type 2 diabetes prevention)
  • Lifespan extension and anti-aging (confirmed in animal studies)
  • +3 more…
⚠️ Risks
  • None (safety confirmed in clinical trials)

⚗️ Reactions with Substances

Stomach acid (low pH) (Safe) Bile acids (Safe) Spore formation (Safe)
#New finding#Natto#Diabetes#Weight loss#Alzheimer's#Longevity#2023
new 🆕 New

Akkermansia (Next-gen Beneficial Bacteria)

Akkermansia muciniphila

💚 Lv.5
Very Safe

A specialized gut bacterium that degrades and regenerates the intestinal mucus layer (mucin). 2025 research continues to reveal its benefits for obesity, type 2 diabetes, and mental disorders. Recognized worldwide as a 'next-generation beneficial bacterium' that strengthens the intestinal barrier and prevents chronic inflammation. Research in Japan is also accelerating rapidly.

✅ Benefits
  • Strengthens intestinal barrier (improves tight junctions)
  • Reduces obesity and visceral fat (confirmed in clinical trials)
  • Improves blood glucose and HbA1c in type 2 diabetes
  • +3 more…
⚠️ Risks
  • Effects of large doses still under study (normal amounts are safe)
  • Consult a doctor if taking immunosuppressants

⚗️ Reactions with Substances

Mucin (intestinal mucus) (Safe) High-fat diet (Safe) LPS (bacterial endotoxin) (Safe)
#New finding#Next-gen probiotic#Obesity#Diabetes#Gut barrier#2025
No bacteria found. Try different search terms.
DB Last Updated:2026-04-24
⚠️ Disclaimer: Information in this database is for general educational purposes only. It is not a substitute for medical diagnosis or treatment. Consult a doctor or pharmacist for health concerns.